Maté J, Durán R, Lara S, Pajares J M, Moreno-Otero R
Service of Gastroenterology, Hospital de la Princesa, Universidad Autónoma de Madrid.
Hepatogastroenterology. 1993 Oct;40(5):471-4.
In order to determine whether the LDH isoenzyme pattern, measuring the percentages of LDH4-5 (M monomer), might be a marker in the adenoma-carcinoma sequence, 103 adenomas, 8 adenomas with proven malignant degeneration and 27 adenocarcinomas of the large intestine, as well as 12 biopsy samples of colonic mucosa from normal controls, were studied histologically and histochemically. The proportion of M polypeptide was significantly increased in adenomas of larger size (diameter > 2 cm), in adenomas with a larger villous component, and in those with severe dysplasia. The largest proportion of M polypeptide was found in villous adenomas and colloid adenocarcinomas, and might reflect a common origin. These results suggest that the histochemical study of the LDH isoenzymogram might be a useful marker for detecting early malignant degeneration in adenomas of the colon.
为了确定测量乳酸脱氢酶4 - 5（M单体）百分比的乳酸脱氢酶同工酶模式是否可能是腺瘤-癌序列中的一个标志物，对103例大肠腺瘤、8例已证实有恶性变的腺瘤和27例大肠腺癌，以及12例来自正常对照的结肠黏膜活检样本进行了组织学和组织化学研究。在较大尺寸（直径>2 cm）的腺瘤、具有较大绒毛成分的腺瘤以及有严重发育异常的腺瘤中，M多肽的比例显著增加。在绒毛状腺瘤和黏液腺癌中发现M多肽的比例最高，这可能反映了共同的起源。这些结果表明，乳酸脱氢酶同工酶谱的组织化学研究可能是检测结肠腺瘤早期恶性变的一个有用标志物。
