Lyon D, Howard E B, Montgomerie J Z
Infect Immun. 1982 Nov;38(2):558-62. doi: 10.1128/iai.38.2.558-562.1982.
The effect of cyclophosphamide on urinary tract infection was studied, using Pseudomonas aeruginosa in a murine model. Urinary tract infections were produced by injecting P. aeruginosa through a urethral catheter into the bladders of mice. The number of P. aeruginosa organisms in the bladder tissue and kidneys, histopathology, peripheral leukocyte count, and antibody response to P. aeruginosa was measured. The local effect of cyclophosphamide on the bladder was determined by measuring the bladder tissue water and examining the histopathology. Cyclophosphamide increased the susceptibility of mice to P. aeruginosa urinary tract infection, resulting in marked cystitis and an increase in renal infection, bacteremia, and mortality. These changes correlated with the toxic effect of cyclophosphamide on the wall of the bladder rather than with peripheral leukopenia or failure of antibody response.
在小鼠模型中，使用铜绿假单胞菌研究了环磷酰胺对尿路感染的影响。通过尿道导管将铜绿假单胞菌注入小鼠膀胱来引发尿路感染。测量膀胱组织和肾脏中铜绿假单胞菌的数量、组织病理学、外周白细胞计数以及对铜绿假单胞菌的抗体反应。通过测量膀胱组织含水量并检查组织病理学来确定环磷酰胺对膀胱的局部作用。环磷酰胺增加了小鼠对铜绿假单胞菌尿路感染的易感性，导致明显的膀胱炎以及肾脏感染、菌血症和死亡率增加。这些变化与环磷酰胺对膀胱壁的毒性作用相关，而非与外周白细胞减少或抗体反应失败相关。
