Soyano A, Candellet D, Layrisse M
Int Arch Allergy Appl Immunol. 1982;69(4):353-7. doi: 10.1159/000233199.
To delineate the alterations of the immune function induced by iron deficiency male Sprague-Dawley rats were obtained at 3 weeks of age and fed an iron-deficient diet. By the end of the 3rd week on this diet the animals were anemic and ferropenic. A marked increase in the proliferative response of splenic lymphocytes at optimal doses of mitogen (PHA, Con A, and PWM) was observed. On the contrary, thymic lymphocytes showed a decreased proliferative response. Time-course experiments demonstrated significant alterations in these proliferative responses after only 1 week of iron deprivation, at a time when the level of hemoglobin was normal. Nutritional rehabilitation after 5 weeks of iron deprivation showed complete recovery of the response after 11/2 weeks on normal diet.
为了描述缺铁诱导的免疫功能改变，选用3周龄雄性斯普拉格-道利大鼠，给予缺铁饮食。在这种饮食喂养3周结束时，动物出现贫血和铁缺乏。观察到在有丝分裂原（PHA、Con A和PWM）的最佳剂量下，脾淋巴细胞的增殖反应显著增加。相反，胸腺淋巴细胞的增殖反应降低。时间进程实验表明，在缺铁仅1周后，这些增殖反应就出现了显著改变，此时血红蛋白水平正常。缺铁5周后的营养恢复显示，在正常饮食1.5周后反应完全恢复。
