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上皮内淋巴细胞对T细胞有丝分裂原的反应：小鼠和猪反应的比较。

Responses of intraepithelial lymphocytes to T-cell mitogens: a comparison between murine and porcine responses.

作者信息

Wilson A D, Stokes C R, Bourne F J

出版信息

Immunology. 1986 Aug;58(4):621-5.

PMID:3488265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453105/
Abstract

Intraepithelial lymphocytes (IEL) were isolated from the small intestine of pigs. They showed a strong blastogenic response to the T-cell mitogens phytohaemagglutinin A (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM); in contrast, mouse IEL responded weakly to these mitogens. The response of pig IEL was age-dependent, reaching adult levels by 9 weeks of age. Early weaning of pigs delayed the onset of this response. The effects of inflammatory mediators on the response of mouse IEL were also examined.

摘要

上皮内淋巴细胞（IEL）从小肠中分离出来。它们对T细胞有丝分裂原植物血凝素A（PHA）、刀豆球蛋白A（Con A）和商陆有丝分裂原（PWM）表现出强烈的增殖反应；相比之下，小鼠IEL对这些有丝分裂原的反应较弱。猪IEL的反应具有年龄依赖性，在9周龄时达到成年水平。仔猪早期断奶延迟了这种反应的开始。还研究了炎症介质对小鼠IEL反应的影响。

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本文引用的文献

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Functional characteristics of lymphocytes isolated from the rat large intestine. Response to T-cell mitogens and natural killer cell activity.从大鼠大肠分离的淋巴细胞的功能特性。对T细胞有丝分裂原的反应和自然杀伤细胞活性。
Gastroenterology. 1984 Mar;86(3):468-75.
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Immunologic characteristics of intestinal lymphoid cells of the guinea pig.豚鼠肠道淋巴样细胞的免疫学特性
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The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes.人白细胞介素2产生的抑制机制。II. 前列腺素E2诱导抑制性T淋巴细胞
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