Brown E A, Kliger A S, Finkelstein F O
Nephron. 1978;21(6):310-6. doi: 10.1159/000181409.
This study was designed to (1) develop a simple technique of estimating 'middle-molecule' clearances in peritoneal dialysis patients using vitamin B12 as a marker; (2) evaluate changes in small- and middle-molecule clearances during a single 24- or 36-hour peritoneal dialysis, and (3) determine if using 4.25% rather than 1.5% dextrose exchanges alters the clearances of small and middle molecules. Measurement of clearance following the intramuscular injection of vitamin B12 was found to be a reliable method of estimating the clearance of middle molecules. Small- and middle-molecule clearances remain constant throughout an individual 24- or 36-hour dialysis. In addition, small-molecule clearances increase significantly with 4.25% dextrose dialysate but return to prior values when 1.5% dextrose dialysate is reinstituted.
（1）开发一种使用维生素B12作为标志物来估算腹膜透析患者“中分子”清除率的简单技术；（2）评估单次24或36小时腹膜透析期间小分子和中分子清除率的变化；以及（3）确定使用4.25%而非1.5%葡萄糖交换液是否会改变小分子和中分子的清除率。肌肉注射维生素B12后测量清除率被发现是估算中分子清除率的可靠方法。在个体的24或36小时透析过程中，小分子和中分子清除率保持恒定。此外，4.25%葡萄糖透析液可使小分子清除率显著增加，但重新使用1.5%葡萄糖透析液时又会恢复到先前的值。
