Brown E A, Kliger A S, Goffinet J, Finkelstein F O
Kidney Int. 1978 Apr;13(4):271-7. doi: 10.1038/ki.1978.40.
A model for performing peritoneal dialysis in the rat was established which permitted the consistent measurement of dialysis clearances. The effects on urea and inulin clearances of interperitoneal vasodilators and 4.25% dextrose were compared. Isoproterenol, nitroprusside, histamine, and bradykinin, when added to 1.5% dextrose dialysate for three consecutive exchanges, all produced approximately a 20% increase in urea and inulin dialysis clearances. These increases in clearances persisted in the three subsequent exchanges when no drugs were added to the dialysate. The addition of isoproterenol, nitroprusside, or histamine to six consecutive exchanges did not produce a further increment in clearances. The use of 4.25% dextrose dialysate for three exchanges produced approximately a 50% increase in urea and inulin clearances. Clearances remained about 35% greater than control values in the subsequent three 1.5% dextrose exchanges.
建立了一种大鼠腹膜透析模型，该模型可对透析清除率进行持续测量。比较了腹膜内血管扩张剂和4.25%葡萄糖对尿素和菊粉清除率的影响。当将异丙肾上腺素、硝普钠、组胺和缓激肽连续三次加入1.5%葡萄糖透析液中时，尿素和菊粉透析清除率均提高了约20%。在随后三次透析液中不添加药物的交换过程中，清除率的增加持续存在。连续六次加入异丙肾上腺素、硝普钠或组胺并未使清除率进一步增加。使用4.25%葡萄糖透析液进行三次交换使尿素和菊粉清除率提高了约50%。在随后三次1.5%葡萄糖交换过程中，清除率仍比对照值高约35%。
