Ogawa Y, Kurebayashi N
J Biochem. 1982 Sep;92(3):899-905. doi: 10.1093/oxfordjournals.jbchem.a134004.
Ca-releasing action of halothane on fragmented sarcoplasmic reticulum (FSR) from bullfrog and rabbit skeletal muscle was examined to understand the mechanism of Ca release in reference to the etiology of malignant hyperthermia. Halothane has dual action on FSR: the Ca release and the inhibition of Ca uptake. On addition of halothane to loaded FSR, a rapid Ca release was followed by a sluggish Ca leakage which was probably due to a decreased capacity for Ca uptake. The properties of the rapid Ca release by halothane are similar to those of caffeine. It was inhibited by procaine or high concentrations of Mg2+. It was stimulated by a high concentration of ATP. A low temperature was stimulatory for Ca-releasing action on frog FSR while it was inhibitory on rabbit FSR. The result that caffeine shifted the dose response curve for Ca release by halothane to a steeper relation to a range of much lower concentrations suggests that the action of halothane may not be identical with that of caffeine in spite of many similarities.
研究了氟烷对牛蛙和兔骨骼肌肌浆网片段（FSR）的钙释放作用，以结合恶性高热的病因来理解钙释放机制。氟烷对FSR有双重作用：钙释放和钙摄取抑制。向加载了钙的FSR中添加氟烷后，先是快速的钙释放，接着是缓慢的钙泄漏，这可能是由于钙摄取能力下降所致。氟烷快速钙释放的特性与咖啡因相似。它被普鲁卡因或高浓度的Mg2+抑制。它被高浓度的ATP刺激。低温对青蛙FSR的钙释放作用有刺激作用，而对兔FSR则有抑制作用。咖啡因将氟烷钙释放的剂量反应曲线向更陡峭的关系移动到低得多的浓度范围，这一结果表明，尽管有许多相似之处，但氟烷的作用可能与咖啡因的作用并不相同。
