Zebrowska-Szymusik M
Neurol Neurochir Pol. 1978 Jul-Aug;12(4):427-34.
The author reports the results of investigations on the effect of Phenytoin Polfa on the peripheral motor neuron in relation to the serum drug levels. The investigated group included 42 epileptics treated for 7 to 30 years with phenytoin in daily doses of 300--400 mg. In all cases neurological examination was done, the serum phenytoin level was determined, basic EMG investigation, conduction velocity measurement in motor fibres of peripheral nerves, and stimulation test for disclosing myasthenic fatiguability were performed. In the conclusion the author states that phenytoin in the doses used caused no changes in conduction velocity in the motor fibres. Changes suggesting possible lesion of the peripheral motor neuron were found in only 7.1% of basic EMG records. Evidence of fatiguability in stimulation test was found in 28.6% of cases, they were not correlated with the serum drug level duration of treatment, subjective changes and objective findings.
作者报告了关于苯妥英钠（Polfa）对周围运动神经元的影响与血清药物水平关系的调查结果。研究组包括42例癫痫患者，他们服用苯妥英钠治疗7至30年，日剂量为300 - 400毫克。所有病例均进行了神经学检查，测定了血清苯妥英水平，进行了基本的肌电图检查、外周神经运动纤维传导速度测量以及用于揭示肌无力易疲劳性的刺激试验。作者在结论中指出，所用剂量的苯妥英钠未引起运动纤维传导速度的变化。仅7.1%的基本肌电图记录发现了提示周围运动神经元可能受损的变化。28.6%的病例在刺激试验中发现了易疲劳性证据，这些证据与血清药物水平、治疗持续时间、主观变化和客观发现均无相关性。
