Ingvar M, Siesjö B K
J Cereb Blood Flow Metab. 1982 Dec;2(4):481-6. doi: 10.1038/jcbfm.1982.55.
The influence of 70-80% N2O on local local cerebral glucose utilization (CMRg1) in the rat brain was studied with the [14C]deoxyglucose method in minimally restrained, spontaneously breathing animals 75 min following discontinuation of halothane anaesthesia. Nitrous oxide was found to have only small effects on local CMRg1 in the majority of the 25 structures analyzed. When corrections were made for a small difference in body temperature between nitrous oxide--breathing animals and those breathing air nitrous oxide was found to significantly increase local CMRg1 in some subcortical structures by 15-25% (red nucleus, thalamus, geniculate bodies, and superior colliculus), and to decrease local CMRg1 in nucleus accumbens and sensorimotor cortex by comparable amounts. Thus, although nitrous oxide does not alter overall glucose utilization in the brain, it differentially affects CMRg1 in some brain structures.
采用[14C]脱氧葡萄糖法，在氟烷麻醉停止75分钟后，对轻度约束、自主呼吸的动物进行研究，观察70 - 80%氧化亚氮对大鼠脑局部脑葡萄糖利用（CMRg1）的影响。在分析的25个脑区中的大多数区域，发现氧化亚氮对局部CMRg1仅有微小影响。当对氧化亚氮吸入组动物与空气吸入组动物之间的体温微小差异进行校正后，发现氧化亚氮可使某些皮层下结构（红核、丘脑、膝状体和上丘）的局部CMRg1显著增加15 - 25%，并使伏隔核和感觉运动皮层的局部CMRg1下降相当的幅度。因此，尽管氧化亚氮不会改变脑内总的葡萄糖利用，但它对某些脑区的CMRg1有不同的影响。
