[Enzymatic determination of urinary estrone and estradiol: correlations with plasma estradiol in the menstrual cycle in women].

Enzymatic determination of urine estrone and estradiol concentrations were done daily during a menstrual cycle in six female volunteers. The results were compared with plasma estradiol determined by radioimmunoassay in the same patients. The pattern of estrone and estradiol excretion in morning urine sample fairly reproduced plasma estradiol variations and a good correlation was observed (r = 0.78). The urine pattern of estrone and estradiol variation determined by the enzyme assay can be considered as a good index of oestrogen secretion. The preovulatory peak of estrone and estradiol was observed in urine the day before or the same day as the LH peak. Estrone and estradiol concentration in urine doubled the mean value of the concentration of the follicular phase several days before the LH peak giving a useful indication for prediction of ovulation.