Leitersdorf E, Friedman G, Gozal D, Appelbaum A, Sacks T, Levij I
Med Hypotheses. 1982 Sep;9(3):325-30. doi: 10.1016/0306-9877(82)90162-1.
During the years 1970-1980, 697 patients had valve replacement surgery at our institution. Thirty patients subsequently developed prosthetic valve endocarditis (P.V.E.). Reexamination of the native valves of 25 of these patients revealed histopathological evidence of thromboendocarditis in 7, 5 of whom subsequently developed early P.V.E. In 3 out of 25 matched controls in whom P.V.E. was not diagnosed clinically, similar pathological findings were found; these patients all had fever pre- or post-operatively and were treated with a short antibacterial course, but no definite clinical diagnosis was made. We suggest that there is a close relationship between subclinical thromboendocarditis on the native valve and the early development of infective endocarditis on the implanted artificial valve.
1970年至1980年间，我院有697例患者接受了瓣膜置换手术。其中30例患者随后发生了人工瓣膜心内膜炎（P.V.E.）。对其中25例患者的自体瓣膜进行复查发现，7例有血栓性心内膜炎的组织病理学证据，其中5例随后发生了早期P.V.E.。在25例未临床诊断为P.V.E.的匹配对照者中，有3例发现了类似的病理结果；这些患者术前或术后均有发热，接受了短期抗菌治疗，但未作出明确的临床诊断。我们认为，自体瓣膜上的亚临床血栓性心内膜炎与植入人工瓣膜上感染性心内膜炎的早期发生密切相关。
