Saavedra J M
Neuroendocrinology. 1982 Nov;35(5):396-401. doi: 10.1159/000123413.
Acute immobilization stress results in changes in the concentration of both dopamine and noradrenaline in specific forebrain limbic system areas, whereas the adrenaline levels remain unchanged. Changes in dopamine concentrations are more restricted than those in noradrenaline concentrations. Dopamine levels are increased in the nucleus preopticus medialis, 2 and 4 h after stress, and decreased in the nucleus septalis lateralis, throughout the acute stress period. The noradrenaline levels are also increased in the nucleus preopticus medialis 2 and 4 h after stress. In most septal stress, and in the nucleus interstitialis striae terminalis, the noradrenaline levels are decreased early during acute stress, but return to normal values after 2-4 h of continuous stress. In the nucleus septalis intermediate, on the other hand, the noradrenaline levels are increased, and the change occurs only after 4 h of stress. These results suggest a participation of both noradrenaline levels are increased, and the change occurs only after 4 h of stress. These results suggest a participation of both noradrenaline levels are increased, and the change occurs only after 4 h of stress. These results suggest a participation of both noradrenaline and dopamine neurons in the central response to the stress reaction and the existence of fast adaptive changes in the metabolism of these biogenic amines in specific areas of the limbic system during stress.
急性制动应激会导致特定前脑边缘系统区域中多巴胺和去甲肾上腺素的浓度发生变化，而肾上腺素水平保持不变。多巴胺浓度的变化比去甲肾上腺素浓度的变化更具局限性。应激后2小时和4小时，视前内侧核中的多巴胺水平升高，而在整个急性应激期，外侧隔核中的多巴胺水平降低。应激后2小时和4小时，视前内侧核中的去甲肾上腺素水平也会升高。在大多数隔区应激中，终纹床核间质性核中的去甲肾上腺素水平在急性应激早期降低，但在持续应激2 - 4小时后恢复到正常水平。另一方面，在中间隔核中，去甲肾上腺素水平升高，且这种变化仅在应激4小时后发生。这些结果表明，去甲肾上腺素和多巴胺神经元都参与了对应激反应的中枢应答，并且在应激期间边缘系统特定区域中这些生物胺的代谢存在快速适应性变化。
