Saavedra J M, Kvetnansky R, Kopin I J
Brain Res. 1979 Jan 12;160(2):271-80. doi: 10.1016/0006-8993(79)90424-4.
Catecholamines (adrenaline, noradrenaline and dopamine) have been measured in specific areas of the rat brain stem after acute immobilization stress. Adrenaline levels were significantly decreased after 240 min of immobilization in all areas studied: A1 area, nucleus commissuralis (NCO), A2 area, anterior part of the nucleus tractus solitarii (NTS), and the locus coeruleus. Noradrenaline concentrations in stressed rats were significantly reduced only in the NTS area. In contrast, during stress there were no significant changes in dopamine concentrations with respect to control values in any of the areas studied. These results implicate the participation of central adrenaline neurons, localized in specific brain stem areas, and noradrenaline neurons innervating the rostral part of the nucleus tractus solitarii, in the mechanism of central response to acute stress.
在急性固定应激后，已对大鼠脑干的特定区域中的儿茶酚胺（肾上腺素、去甲肾上腺素和多巴胺）进行了测量。在所有研究区域中，固定240分钟后肾上腺素水平均显著降低：A1区、连合核（NCO）、A2区、孤束核（NTS）前部以及蓝斑。应激大鼠中去甲肾上腺素浓度仅在NTS区域显著降低。相比之下，在应激期间，所研究的任何区域中多巴胺浓度与对照值相比均无显著变化。这些结果表明，位于特定脑干区域的中枢肾上腺素能神经元以及支配孤束核头端部分的去甲肾上腺素能神经元参与了对急性应激的中枢反应机制。
