[Use of disulfiram in a histochemical study of the influence of different stimuli on the concentration of noradrenaline in brain structures].

With the help of the histochemical fluorescence method the changes in noradrenaline fluorescence of nuc. septi lateralis, nuc. interstitialis striae terminalis and nuc. preoticus medialis during conditioning and unconditioned stimulation were studied. In 135 disulfiram pretreated rats the depletion of noradrenaline fluorescence in the investigated structures was found after electro-stimulation of feet during 5 min., 1 and 2 hours, open-field behavior and reproduction of a conditioned avoidance response. Twelve hours after disulphiram administration the suppression of the open-field behavior and reproduction of the conditioned avoidance response as well as the depletion of noradrenaline fluorescence in the investigated structures were detected.