Favilli S, Iacopetti L, Fradella G A, Righi D, Nuzzaci G
Pharmatherapeutica. 1982;3(4):221-6.
A study was carried out in 13 patients with stabilized occlusive arterial disease to assess the effect of treatment with creatine phosphate (800 mg/day for 12 days) on walking distance to onset of disabling pain and on haemodynamic parameters (Winsor Index and calf arterial blood flow after ischaemia). Before treatment, patients had daily exercise for 12 days on a treadmill to plateau walking distance increase due to exercise. The results showed a further significant increase in walking distance after treatment, and a significant increase in peak reactive hyperaemia in all but 2 patients. The possible mechanisms of the effects of creatine phosphate are discussed.
对13例病情稳定的闭塞性动脉疾病患者进行了一项研究，以评估磷酸肌酸治疗（800毫克/天，持续12天）对出现致残性疼痛时的步行距离以及血流动力学参数（温索尔指数和缺血后小腿动脉血流量）的影响。治疗前，患者在跑步机上每天锻炼12天，以使步行距离因锻炼而增加达到稳定状态。结果显示，治疗后步行距离进一步显著增加，除2例患者外，所有患者的反应性充血峰值均显著增加。文中讨论了磷酸肌酸作用的可能机制。
