Panchenko E, Dobrovolsky A, Rogoza A, Sorokin E, Ageeva N, Markova L, Titaeva E, Anuchin V, Karpov Y, Saks V
Cardiology Research Center, Moscow, Russia.
Int Angiol. 1994 Mar;13(1):59-64.
Thirty-seven men with angiography or ultrasound confirmed peripheral arterial occlusive disease were divided into two groups. Group 1 included 24 patients treated with one daily infusion of 10 g of phosphocreatine in 200 ml of solvent for 10 days. Group 2 included 13 patients who were given 0.9% NaCl in the same scheme. Groups were comparable in: duration of intermittent claudication, maximal walking distance, Ketle index, cholesterol, triglycerides, frequency of ischemic heart disease, hypertension, diabetes, smoking. Patients were examined 4 times: before starting, on second day, after treatment period, and 1 month after. Treadmill-test; ADP-, PAF-, 5-HT-induced platelet aggregation; D-dimer; PAI-1 activity; blood viscosity at high and low shear rate; hematocrit were performed. After treatment maximal walking distance significantly increased in patients of Group 1. Mechanisms of this effects include positive influence of phosphocreatine on platelet aggregation, blood rheology, coagulation and fibrinolytic systems.
37名经血管造影或超声检查确诊为外周动脉闭塞性疾病的男性被分为两组。第一组包括24名患者，他们每天接受一次将10克磷酸肌酸溶于200毫升溶剂中的输注，共10天。第二组包括13名患者，他们按照相同方案接受0.9%氯化钠治疗。两组在以下方面具有可比性：间歇性跛行持续时间、最大行走距离、凯特尔指数、胆固醇、甘油三酯、缺血性心脏病频率、高血压、糖尿病、吸烟情况。患者接受4次检查：开始前、第二天、治疗期结束后以及治疗后1个月。进行了跑步机测试、ADP、PAF、5-羟色胺诱导的血小板聚集、D-二聚体、PAI-1活性、高低切变率下的血液粘度、血细胞比容等检查。治疗后，第一组患者的最大行走距离显著增加。这种作用的机制包括磷酸肌酸对血小板聚集、血液流变学、凝血和纤维蛋白溶解系统的积极影响。
