Gnarpe H, Kinnman G, Fanfani A
Pharmatherapeutica. 1982;3(4):283-8.
Forty-nine hospital patients with symptoms of urinary tract infection and significant bacteriuria were treated with a fixed combination of 250 mg trimethoprim and 200 mg sulfamethopyrazine, 2 capsules on the first day and 1 capsule daily for a further 6 days. Mixed infections were frequent. A total of 67 infecting organisms was isolated on admission, and 85% of them were eradicated, as shown by urine cultures carried out 3 to 10 days after the end of treatment. Overall therapeutic results were assessed as excellent or good in 75% of the patients. Only one side-effect, of allergic type, was observed among the 49 cases treated. The combination of trimethoprim and sulfamethopyrazine is considered as suitable for hospital or home treatment of acute and recurrent urinary tract infections.
49例有尿路感染症状且菌尿显著的住院患者接受了250毫克甲氧苄啶与200毫克磺胺甲氧嗪的固定复方治疗，首日服用2粒胶囊，之后6天每日服用1粒胶囊。混合感染很常见。入院时共分离出67种感染病原体，治疗结束后3至10天进行的尿培养显示，其中85%的病原体被根除。75%的患者总体治疗结果评估为优或良。在接受治疗的49例病例中，仅观察到1例过敏型副作用。甲氧苄啶与磺胺甲氧嗪的复方被认为适用于医院或家庭治疗急性和复发性尿路感染。
