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多巴胺能伏隔核损伤对大鼠按计划诱导自我注射尼古丁习得的影响。

Effects of dopaminergic nucleus accumbens lesions on the acquisition of schedule induced self injection of nicotine in the rat.

作者信息

Singer G, Wallace M, Hall R

出版信息

Pharmacol Biochem Behav. 1982 Sep;17(3):579-81. doi: 10.1016/0091-3057(82)90321-5.

DOI:10.1016/0091-3057(82)90321-5
PMID:7146054
Abstract

Data from recent experiments show that dopaminergic depletion of the nucleus accumbens septum (NAS) decreases the frequency of schedule induced drinking and wheel running. In the present experiment a group of 8 rats with 6-OHDA lesions in the NAS showed a significantly lower rate of schedule induced nicotine self injection than sham operated controls. These findings extend the number of schedule induced behaviors which appear to depend for their occurrence on an intact dopamine system in the NAS.

摘要

近期实验数据表明，伏隔核（NAS）的多巴胺能耗竭会降低定时诱导饮水和轮转运动的频率。在本实验中，一组8只在NAS中存在6-羟基多巴胺损伤的大鼠，其定时诱导尼古丁自我注射的速率显著低于假手术对照组。这些发现扩展了定时诱导行为的数量，这些行为的发生似乎依赖于NAS中完整的多巴胺系统。

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