Korsatko W, Porta S, Sadjak A, Supanz S
Pharmazie. 1982 Aug;37(8):565-7.
Implantable coated Eudragit matrix tablets containing adrenaline in various concentrations should overcome the problem of additional handling stress during long term infusions. The efficiency of those tablets was tested in vitro, as well as in vivo using labeled adrenaline. Both in vitro and in vivo testing yielded satisfactorily output rates up to 20 h whereby the liver and serum content of 14C-fragments served as an additional prove for the postulated mode of action. Good correlation has been found between the mentioned out-put rates and adrenaline serum levels (measured according to Da Prada).
含有不同浓度肾上腺素的可植入包衣型丙烯酸树脂基质片应能解决长期输注过程中额外处理压力的问题。这些片剂的有效性在体外以及使用标记肾上腺素进行的体内实验中进行了测试。体外和体内测试均产生了令人满意的长达20小时的输出速率，其中14C片段的肝脏和血清含量作为假定作用方式的额外证据。已发现上述输出速率与肾上腺素血清水平（根据达普拉达方法测量）之间具有良好的相关性。
