The suitability of a combined inulin/PAH retard tablet for measuring renal functions in the conscious rat.

As a further step in the development of implantable retard systems for simultaneous delivery of inulin and PAH, a system based on Eudragit matrix retard tablet has been deviced. It should be able to release a sufficient amount of both substances to maintain constant and well measurable serum and urine concentration in the 36 hours interval between 12-48 hours p.o. The feasibility of the technique was checked by monitoring the behaviour of renal function after administration of a permanent adrenaline application, which we used as a well defined noxa.