Day H D, Han Y K
Physiol Behav. 1982 Aug;29(2):387-91. doi: 10.1016/0031-9384(82)90031-2.
To examine time-dependent recovery from ECS-induced amnesia, 44 hooded rats were trained to leverpress for food. On treatment day the first leverpress was followed by footshock and ECS or sham ECS (SECS). Animals in both treatment conditions then experienced a 10-min extinction session either 1 or 3 days following treatment. For both the 1-day and 3-day delay ECS groups, the latencies to the first response during extinction were lower than the latencies of the corresponding SECS groups. When extinction followed treatment by 1 day, the ECS rats also made more responses during the test than the SECS rats; however, when tested 3 days after treatment, the ECS and SECS groups did not differ on extinction response rate. In this operant setting, therefore, time-dependent recovery from amnesia can be demonstrated with response rate as the amnesia measure. In addition, since both groups of SECS animals exhibited significant interrelationships of measures following treatment and the same measures were not associated in the ECS groups, it was hypothesized that the proactive effects of ECS include a reduction in the stability of performance.
为了研究电休克惊厥（ECS）诱导失忆后的时间依赖性恢复情况，对44只戴帽大鼠进行训练，使其通过按压杠杆获取食物。在治疗日，首次按压杠杆后随即施加足部电击以及ECS或假电休克惊厥（SECS）。然后，两种治疗条件下的动物在治疗后1天或3天经历10分钟的消退训练。对于1天延迟和3天延迟的ECS组，消退期间首次反应的潜伏期均低于相应SECS组的潜伏期。当在治疗后1天进行消退训练时，ECS大鼠在测试期间的反应次数也比SECS大鼠多；然而，在治疗后3天进行测试时，ECS组和SECS组在消退反应率上没有差异。因此，在这种操作性实验环境中，以反应率作为失忆指标可以证明失忆存在时间依赖性恢复。此外，由于两组SECS动物在治疗后的测量指标之间表现出显著的相互关系，而ECS组中相同的测量指标并无关联，因此推测ECS的前摄效应包括降低行为表现的稳定性。
