[分离的大鼠肝细胞中酮糖引起的克氏效应]
[Crabtree effect caused by ketoses in isolated rat hepatocytes].
作者信息
Martínez P, Carrascosa J M, Núñez de Castro I
出版信息
Rev Esp Fisiol. 1982;38 Suppl:181-3.
PMID:7146574
Abstract
Oxygen uptake and glycolytic activity were studied in hepatocytes isolated from fed rats. The addition of fructose or tagatose resulted in a 38% and 31% inhibition of cellular respiration respectively. The addition of 10 mM D-glyceraldehyde caused a slight Crabtree effect. Glucose, L-sorbose, or glycerol failed to modify oxygen consumption. Only incubation in the presence of fructose showed a high aerobic glycolysis measured by lactate production.
摘要
在从喂食大鼠分离的肝细胞中研究了氧摄取和糖酵解活性。添加果糖或塔格糖分别导致细胞呼吸抑制38%和31%。添加10 mM D-甘油醛引起轻微的克氏效应。葡萄糖、L-山梨糖或甘油未能改变氧消耗。只有在果糖存在下孵育时，通过乳酸生成测量显示出高需氧糖酵解。
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