Martínez P, Núñez de Castro I
Enzyme. 1980;25(6):377-81. doi: 10.1159/000459285.
The inhibition of respiration caused by fructose is investigated in hepatocytes isolated from regenerating liver. After partial hepatectomy, decreased respiratory capacity of the cells was observed in spite of significantly enhanced levels per milligram of protein of cytochromes b and aa3 in the mitochondrial fraction. During the first few days after operation fructose did not affect the oxygen uptake. From the 10th day after surgery incubation with 10 mmol/l fructose caused an increase in the glycolytic flux parallel with an inhibition of respiration.
在从再生肝脏分离出的肝细胞中研究了果糖对呼吸的抑制作用。部分肝切除术后，尽管线粒体部分每毫克蛋白质中细胞色素b和aa3的水平显著提高，但仍观察到细胞呼吸能力下降。术后头几天，果糖不影响氧气摄取。从手术后第10天开始，用10 mmol/l果糖孵育会导致糖酵解通量增加，同时呼吸受到抑制。
