Brada Z, Altman N H, Hill M, Bulba S
Res Commun Chem Pathol Pharmacol. 1982 Oct;38(1):157-60.
Female Wistar rats were fed a semisynthetic diet containing 0.3% DL-ethionine for 52 weeks and, most of them bearing hepatocellular carcinomas, were switched to a basal diet for one week and then received 80 mg DL-methionine per rat (cir. 25 mg/100 g body wt) by gavage once per day, five times a week, over a period of 13 weeks. Methionine treatment significantly affected progression of hepatic tumors induced by DL-ethionine administration. The frequency of rats with hepatocellular carcinomas in the methionine treated group was significantly lower than that in control groups. It therefore appears that methionine treatment resulted in a remission of the malignant process.
将雌性Wistar大鼠用含0.3% DL-乙硫氨酸的半合成饲料喂养52周，其中大多数大鼠患肝细胞癌，然后换用基础饲料一周，接着每只大鼠每天经口灌喂80 mg DL-甲硫氨酸（约25 mg/100 g体重），每周5次，持续13周。甲硫氨酸治疗显著影响了DL-乙硫氨酸诱导的肝肿瘤进展。甲硫氨酸治疗组中患肝细胞癌的大鼠频率显著低于对照组。因此，甲硫氨酸治疗似乎使恶性进程得到缓解。
