Shinozuka H, Lombardi B, Sell S, Iammarino R M
J Natl Cancer Inst. 1978 Sep;61(3):813-7.
The effects of a choline-devoid (CD) or a choline-supplemented (CS) diet on the induction of liver tumors in rats by DL-ethionine were investigated. Groups of male outbred Sprague-Dawley rats were fed a plain CD or a plain CS diet, or the same diets containing 0.05% DL-ethionine. Hepatocellular carcinomas developed in 50% of the rats fed the CD+ethionine diet for 14 weeks and in about 80% of the rats fed the same diet for 22-30 weeks. No hepatocellular carcinomas developed in rats fed the CS+ethionine diet, the plain CD diet, or the plain CS diet up to 30 weeks. The findings suggest that a CD diet alters the response of rat liver to DL-ethionine and leads to an early and enhanced induction of hepatocellular carcinoma.
研究了缺乏胆碱（CD）或补充胆碱（CS）的饮食对DL-乙硫氨酸诱导大鼠肝脏肿瘤的影响。将雄性远交系斯普拉格-道利大鼠分组，分别喂食普通CD饮食、普通CS饮食或含0.05% DL-乙硫氨酸的相同饮食。喂食CD+乙硫氨酸饮食14周的大鼠中，50%发生了肝细胞癌；喂食相同饮食22 - 30周的大鼠中，约80%发生了肝细胞癌。在长达30周的时间里，喂食CS+乙硫氨酸饮食、普通CD饮食或普通CS饮食的大鼠均未发生肝细胞癌。这些发现表明，CD饮食改变了大鼠肝脏对DL-乙硫氨酸的反应，并导致肝细胞癌的早期诱导和诱导增强。
