Millhorn D E, Eldridge F L, Waldrop T G
Respir Physiol. 1982 Jul;49(1):41-8. doi: 10.1016/0034-5687(82)90102-5.
The respiratory response to afferent input from both peripheral and central chemoreceptors can be decreased progressively by bilateral graded cooling of the intermediate, or I(s), areas of the ventral medulla (Millhorn et al., 1982). The present study was undertaken to determine if the phrenic nerve response to calf muscle afferent test stimulation is also affected by graded cooling of the I(s) areas. Anesthetized, paralyzed cats whose vagi and carotid sinus nerves had been cut were studied. Unlike the response to chemoreceptor input, the response to calf muscle input was not affected by moderate (40 degrees C to 20 degrees C) cooling of the I(s) areas. Thus, we conclude that input from both chemoreceptors travels to the respiratory controller via a common pathway that includes the I(s) areas, whereas input from peripheral muscle reaches the controller via an independent pathway that does not include the I(s) areas.
通过对延髓腹侧中间区域（即I(s)区）进行双侧分级降温，对来自外周和中枢化学感受器的传入输入的呼吸反应会逐渐降低（米尔霍恩等人，1982年）。本研究旨在确定膈神经对小腿肌肉传入测试刺激的反应是否也受I(s)区分级降温的影响。对已切断迷走神经和颈动脉窦神经的麻醉、麻痹猫进行了研究。与对化学感受器输入的反应不同，对小腿肌肉输入的反应不受I(s)区适度（40摄氏度至20摄氏度）降温的影响。因此，我们得出结论，来自化学感受器的输入均通过一条包括I(s)区的共同通路传至呼吸控制中枢，而来自外周肌肉的输入则通过一条不包括I(s)区的独立通路传至呼吸控制中枢。
