Hancock B W, Dunsmore I R, Swan H T
Scand J Haematol. 1982 Sep;29(3):193-9.
Pretreatment peripheral blood lymphocyte counts have been recorded in 181 consecutive untreated patients with histologically proven Hodgkin's disease and the patients followed prospectively to determine the relationship of lymphopenia to survival. Lymphocyte counts at presentation did not correspond with histology type but were lower in stage 4 disease. Survival in the 77 patients with lymphocyte counts of less than 1.5 X 10(9)/l was 49.7% which was significantly worse (P less than 0.0001) than the 74.2% survival of those with 'normal' counts. This difference was maintained even after adjustment for other acknowledged prognostic variables including sex, age, stage, symptom status, histology type, and response to treatment. The study provides evidence that the lymphocyte count can be used as a meaningful marker in the clinical staging of Hodgkin's disease.
对181例未经治疗且经组织学证实为霍奇金病的连续患者记录了预处理外周血淋巴细胞计数，并对患者进行前瞻性随访，以确定淋巴细胞减少与生存的关系。就诊时的淋巴细胞计数与组织学类型不相关，但在IV期疾病中较低。淋巴细胞计数低于1.5×10⁹/L的77例患者的生存率为49.7%，显著低于“正常”计数患者的74.2%生存率（P＜0.0001）。即使在对包括性别、年龄、分期、症状状态、组织学类型和治疗反应等其他公认的预后变量进行调整后，这种差异仍然存在。该研究提供了证据表明淋巴细胞计数可作为霍奇金病临床分期中有意义的标志物。
