Kotlarek-Haus S, Gabryś K, Starzyk H, Sciborski R, Gałazka Z
Arch Geschwulstforsch. 1982;52(4):293-301.
Material of 150 patients with Hodgkin's disease was demonstrated and analyzed as to the prognostic significance of factors such as clinical advancement of the disease, histology, sex and age. Median survival time differed significantly in various clinical stages, being in I-III A stages as long as 8.0 years, in III B--5.5 and in IV B--3.4. Median survival time in relative to histologic pattern did not differ significantly in spite of fact that that of LD form was about 2 years shorter than of 3 remaining types. Mean but not median survival time of women was significantly longer than that of men: women were at presentation at less advanced clinical stages and in LD type showed more favourable clinical course than men, but not in NS type. Presence of systemic symptoms was also determinant of worse prognosis. It was observed that simultaneous incidence of unfavourable prognostic factor as LD histology, male sex and advanced clinical stage markedly worsened prognosis.
对150例霍奇金病患者的资料进行了展示和分析，以探讨疾病临床进展、组织学、性别和年龄等因素的预后意义。不同临床分期的中位生存时间差异显著，Ⅰ - ⅢA期长达8.0年，ⅢB期为5.5年，ⅣB期为3.4年。尽管淋巴细胞消减型（LD）的中位生存时间比其余三种类型短约2年，但相对于组织学类型而言，中位生存时间差异不显著。女性的平均生存时间（而非中位生存时间）显著长于男性：女性就诊时临床分期较晚，且在LD型中临床病程比男性更有利，但在结节硬化型（NS）中并非如此。全身症状的出现也是预后较差的决定因素。据观察，LD组织学、男性性别和晚期临床分期等不良预后因素同时出现会显著恶化预后。
