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[补骨脂素加长波紫外线及选择性紫外线光疗法治疗的比较免疫学研究]

[Comparative immunologic studies in PUVA and SUP (selected ultraviolet phototherapy) treatments].

作者信息

Simon N, Hunyadi J

出版信息

Z Hautkr. 1982 Sep 1;57(17):1268-73.

PMID:7148058
Abstract

10 PUVA and 13 SUP-treated psoriatic patients were examined immunologically. The proportion of sheep and mouse erythrocyte rosette forming lymphocytes, the leucocyte migration inhibitory assay, the lymphocyte transformation test were carried out and the suppressor function of peripheral blood mononuclear cells was measured before and 48 hours after the clearing of lesions. The results observed before and after the treatment were compared to each other and to the values of healthy volunteers. No significant difference was observed between the results obtained before and after the treatment, meaning that the immune alterations, which have been observed by several authors immediately after PUVA therapy or UV light irradiation, were not detectable if the tests wer made 48 hours later than the last treatment. The significantly decreased suppressor function of peripheral blood mononuclear cells was not changed during the therapy either.

摘要

对10名接受补骨脂素加长波紫外线(PUVA)治疗和13名接受短程紫外线(SUP)治疗的银屑病患者进行了免疫学检查。进行了绵羊和小鼠红细胞玫瑰花结形成淋巴细胞比例、白细胞迁移抑制试验、淋巴细胞转化试验,并在皮损消退前和消退后48小时测量外周血单个核细胞的抑制功能。将治疗前后观察到的结果相互比较,并与健康志愿者的值进行比较。治疗前后获得的结果之间未观察到显著差异,这意味着如果在最后一次治疗后48小时进行检测,几位作者在PUVA治疗或紫外线照射后立即观察到的免疫改变是检测不到的。外周血单个核细胞显著降低的抑制功能在治疗期间也没有改变。

相似文献

3
Abnormal lymphocyte function following long-term PUVA therapy for psoriasis.
Br J Dermatol. 1983 Apr;108(4):445-50. doi: 10.1111/j.1365-2133.1983.tb04597.x.

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