Steigleder G K, Orfanos C E, Pullmann H
Z Hautkr. 1979 Jan 1;54(1):19-23.
27 patients with generalized psoriasis were treated with oral administration of Ro 10-9359 (50--75 mg/d) and daily radiations with a source emitting UVA and UVB light at 292.5--335 nm (so called selective UV-phototherapy, SUP). In 24 patients full remission was seen, partly with few remaining lesions at the predilection sites. The average number of sessions necessary for clearing was 21.6 in 5.3 weeks. The total energy required was 68 J/cm2. Only slight side effects, such as cheilitis and hair loss (4 cases) were seen. The clinical efficacy of this combined retinoid-UV-treatment is comparable to the therapeutic effect of systemic PUVA; however, its practicability seems to be higher, and its application on an out-patient basis better.
27例泛发性银屑病患者接受口服Ro 10-9359（50-75毫克/天）治疗，并每天接受来自发射波长为292.5-335纳米的UVA和UVB光的光源照射（即所谓的选择性紫外线光疗法，SUP）。24例患者实现完全缓解，部分患者在好发部位仅残留少量皮损。清除皮损所需的平均疗程为21.6次，历时5.3周。所需的总能量为68焦/平方厘米。仅观察到轻微的副作用，如唇炎和脱发（4例）。这种维甲酸与紫外线联合治疗的临床疗效与系统性PUVA的治疗效果相当；然而，其实用性似乎更高，且更适合门诊应用。
