甲状腺功能减退大鼠在同位素平衡状态下，甲状腺素在多个器官局部转化为3,5,3'-三碘甲状腺原氨酸并转变为细胞内3,5,3'-三碘甲状腺原氨酸的作用。 - Suppr

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Contribution fron local conversion of thyroxine to 3,5,3'-triiodothyronine to intracellular 3,5,3'-triiodothyronine in several organs in hypothyroid rats at isotope equilibrium.

作者信息

van Doorn J, Roelfsema F, van der Heide D

出版信息

Acta Endocrinol (Copenh). 1982 Nov;101(3):386-96. doi: 10.1530/acta.0.1010386.

DOI:10.1530/acta.0.1010386

PMID:7148336

Abstract

摘要

相似文献

Contribution fron local conversion of thyroxine to 3,5,3'-triiodothyronine to intracellular 3,5,3'-triiodothyronine in several organs in hypothyroid rats at isotope equilibrium.甲状腺功能减退大鼠在同位素平衡状态下，甲状腺素在多个器官局部转化为3,5,3'-三碘甲状腺原氨酸并转变为细胞内3,5,3'-三碘甲状腺原氨酸的作用。

Acta Endocrinol (Copenh). 1982 Nov;101(3):386-96. doi: 10.1530/acta.0.1010386.

Sources and quantity of 3,5,3'-triiodothyronine in several tissues of the rat.大鼠多个组织中3,5,3'-三碘甲状腺原氨酸的来源与含量

J Clin Invest. 1983 Nov;72(5):1778-92. doi: 10.1172/JCI111138.

Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats.甲状腺功能正常和甲状腺功能减退大鼠甲状腺外三碘甲状腺原氨酸生成途径的定性和定量差异。

J Clin Invest. 1984 Apr;73(4):898-907. doi: 10.1172/JCI111313.

Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine to nuclear triiodothyronine receptor saturation in pituitary, liver, and kidney of hypothyroid rats. Further evidence relating saturation of pituitary nuclear triiodothyronine receptors and the acute inhibition of thyroid-stimulating hormone release.甲状腺功能减退大鼠垂体、肝脏和肾脏中血浆三碘甲状腺原氨酸及局部甲状腺素单碘脱碘作用对三碘甲状腺原氨酸与核三碘甲状腺原氨酸受体饱和的贡献。关于垂体细胞核三碘甲状腺原氨酸受体饱和与促甲状腺激素释放急性抑制之间关系的进一步证据。

J Clin Invest. 1978 May;61(5):1247-59. doi: 10.1172/JCI109041.

The contribution of local thyroxine monodeiodination to intracellular 3,5, 3'-triiodothyronine in several tissues of hyperthyroid rats at isotopic equilibrium.在同位素平衡状态下，局部甲状腺素单碘脱碘对甲状腺功能亢进大鼠多个组织细胞内3,5,3'-三碘甲状腺原氨酸的贡献。

Endocrinology. 1984 Jul;115(1):174-82. doi: 10.1210/endo-115-1-174.

Effect of alterations in thyroid status on the metabolism of thyroxine and triiodothyronine by rat pituitary gland in vitro.甲状腺状态改变对大鼠垂体体外甲状腺素和三碘甲状腺原氨酸代谢的影响。

J Clin Invest. 1982 Apr;69(4):799-808. doi: 10.1172/jci110519.

Inhibition of intrapituitary thyroxine to 3.5.3'-triiodothyronine conversion prevents the acute suppression of thyrotropin release by thyroxine in hypothyroid rats.抑制垂体甲状腺素向3,5,3'-三碘甲状腺原氨酸的转化可防止甲状腺功能减退大鼠中甲状腺素对促甲状腺激素释放的急性抑制作用。

J Clin Invest. 1979 Jul;64(1):117-28. doi: 10.1172/JCI109430.

Production rates and turnover of triiodothyronine in rat-developing cerebral cortex and cerebellum. Responses to hypothyroidism.大鼠发育中的大脑皮层和小脑中三碘甲状腺原氨酸的产生率和周转率。对甲状腺功能减退的反应。

J Clin Invest. 1984 Sep;74(3):1035-49. doi: 10.1172/JCI111471.

Iodothyronine metabolism in liver and kidney homogenates from hyperthyroid and hypothyroid rats.甲状腺功能亢进和甲状腺功能减退大鼠肝脏和肾脏匀浆中的碘甲状腺原氨酸代谢

Endocrinology. 1978 Jul;103(1):156-61. doi: 10.1210/endo-103-1-156.

Brain cortex reverse triiodothyronine (rT3) and triiodothyronine concentrations under steady state infusions of thyroxine and rT3.在甲状腺素和反三碘甲状腺原氨酸稳态输注情况下脑皮质中的反三碘甲状腺原氨酸（rT3）和三碘甲状腺原氨酸浓度。

Endocrinology. 1987 Apr;120(4):1590-6. doi: 10.1210/endo-120-4-1590.

引用本文的文献

Restoration of euthyroidism with levothyroxine: implications of etiology of hypothyroidism and the degree of residual endogenous thyroid function.用左甲状腺素恢复甲状腺功能正常：甲状腺功能减退症病因和残留内源性甲状腺功能程度的影响。

Front Endocrinol (Lausanne). 2022 Jul 22;13:934003. doi: 10.3389/fendo.2022.934003. eCollection 2022.

Possible role of glial cells in the relationship between thyroid dysfunction and mental disorders.胶质细胞在甲状腺功能障碍与精神障碍关系中的可能作用。

Front Cell Neurosci. 2015 Jun 3;9:194. doi: 10.3389/fncel.2015.00194. eCollection 2015.

Action of thyroid hormone in brain.甲状腺激素在大脑中的作用。

J Endocrinol Invest. 2002 Mar;25(3):268-88. doi: 10.1007/BF03344003.

Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems.2型碘甲状腺原氨酸脱碘酶在甲状腺功能减退大鼠脑内的表达表明甲状腺激素在特定初级感觉系统发育中起重要作用。

J Neurosci. 1999 May 1;19(9):3430-9. doi: 10.1523/JNEUROSCI.19-09-03430.1999.

The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain.2型碘甲状腺原氨酸脱碘酶主要在新生大鼠大脑的神经胶质细胞中表达。

Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10391-6. doi: 10.1073/pnas.94.19.10391.

Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats.如对甲状腺切除的大鼠所做的研究表明，单独使用甲状腺素对甲状腺功能减退进行替代治疗并不能确保所有组织均处于甲状腺功能正常状态。

J Clin Invest. 1995 Dec;96(6):2828-38. doi: 10.1172/JCI118353.

Iodothyronine deiodinase activity in methionine-deficient rats fed selenium-deficient or selenium-sufficient diets.在喂食缺硒或富硒日粮的蛋氨酸缺乏大鼠体内的碘甲状腺原氨酸脱碘酶活性。

Biol Trace Elem Res. 1995 May;48(2):197-213. doi: 10.1007/BF02789192.

The effect of GHRH on TSH release in rats in vivo and in vitro.生长激素释放激素（GHRH）对大鼠体内及体外促甲状腺激素（TSH）释放的影响。

J Endocrinol Invest. 1995 Mar;18(3):214-9. doi: 10.1007/BF03347804.

Sources and quantity of 3,5,3'-triiodothyronine in several tissues of the rat.大鼠多个组织中3,5,3'-三碘甲状腺原氨酸的来源与含量

J Clin Invest. 1983 Nov;72(5):1778-92. doi: 10.1172/JCI111138.

Dual mechanisms of regulation of type I iodothyronine 5'-deiodinase in the rat kidney, liver, and thyroid gland. Implications for the treatment of hyperthyroidism with radiographic contrast agents.大鼠肾脏、肝脏和甲状腺中I型碘甲状腺原氨酸5'-脱碘酶的双重调节机制。对使用放射造影剂治疗甲状腺功能亢进症的启示。

J Clin Invest. 1988 May;81(5):1476-84. doi: 10.1172/JCI113479.

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