Nunez E A, Gershon M D
Am J Anat. 1982 Oct;165(2):111-20. doi: 10.1002/aja.1001650203.
The fine structure of the follicular (nongranulated) cells of the adenohypophysis of the bat was examined at different periods of the annual life cycle. Follicular cells were found in all regions of the pars distalis of both active and hibernating bats. Throughout the active phase of the life cycle and during most of the hibernating period, the structure of follicular cells is unchanged. Toward the end of hibernation, however, striking ultrastructural changes occur. The most obvious of these alterations is the appearance in follicles of dense rod-shaped bodies within the follicular luminal space. Just prior to arousal, the rodlike bodies become much wider and appear more as paracrystalline aggregates of dense material. Images indicate that the dense rod-shaped bodies are packaged in vesicles in the cytoplasm of the follicular cells. The fusion of the membrane of filled vesicles with the plasma membrane of the follicular cell results in the release of their dense rod-shaped bodies into the follicular lumen by exocytosis. These cyclic ultrastructural changes indicate that follicular cells have a phasic secretory activity.
在蝙蝠一年生命周期的不同阶段，对其腺垂体滤泡（无颗粒）细胞的精细结构进行了检查。在活跃期和冬眠期蝙蝠的远侧部所有区域均发现有滤泡细胞。在生命周期的整个活跃阶段以及大部分冬眠期，滤泡细胞的结构没有变化。然而，在冬眠末期，会出现显著的超微结构变化。其中最明显的改变是在滤泡腔隙内的滤泡中出现密集的杆状体。就在苏醒前，杆状体变得宽得多，看起来更像是密集物质的类晶体聚集体。图像显示，密集的杆状体被包裹在滤泡细胞细胞质中的囊泡内。充满囊泡的膜与滤泡细胞的质膜融合，导致其密集的杆状体通过胞吐作用释放到滤泡腔中。这些周期性的超微结构变化表明滤泡细胞具有阶段性分泌活动。
