McGuire J C, Kelly R C, Gorman R R, Sun F F
Prep Biochem. 1978;8(2-3):147-53. doi: 10.1080/00327487808069056.
A convenient method for the biosynthesis of 12L-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) from archidonic acid with human platelets was developed, and milligram quantities were made for biological and spectroscopic characterization. This compound has only weak activity in two of five biological prostaglandin assays and no activity in the other three. The 13C and 1H NMR spectra of HETE were obtained and the signal due to each carbon atom was assigned.
开发了一种利用人血小板从花生四烯酸生物合成12L-羟基-5,8,10,14-二十碳四烯酸（HETE）的简便方法，并制备了毫克量的该化合物用于生物学和光谱学表征。该化合物在五项生物前列腺素测定中的两项中仅具有微弱活性，在其他三项中无活性。获得了HETE的13C和1H NMR光谱，并对每个碳原子产生的信号进行了归属。
