Forker E L, Luxon B A
Am J Physiol. 1982 Dec;243(6):G532-40. doi: 10.1152/ajpgi.1982.243.6.G532.
In the accompanying paper we explore the analysis of solute disappearance curves using conventional linear assumptions. In this study we extend the analysis to examine the possibility of using the same model to recover the average kinetic parameters when the liver lobule displays anatomic and metabolic heterogeneity. The results show that the linear model can be used to recover good estimates of the average transfer coefficients, even though the kinetic parameters that govern uptake, efflux, and excretion are nonlinear functions of sinusoidal length. The inhomogeneities that we have examined include a variable surface-to-volume ratio of the sinusoids, saturation kinetics at the canalicular face of the liver cells, and a lobular profile of metabolizing enzyme or excretory carrier units per unit length of sinusoid.
在随附的论文中，我们探讨了使用传统线性假设对溶质消失曲线进行分析。在本研究中，我们扩展了分析内容，以检验当肝小叶呈现解剖和代谢异质性时，使用同一模型恢复平均动力学参数的可能性。结果表明，即使控制摄取、外排和排泄的动力学参数是肝血窦长度的非线性函数，线性模型仍可用于获得平均转运系数的良好估计值。我们所研究的不均匀性包括肝血窦可变的表面积与体积比、肝细胞胆小管面的饱和动力学，以及每单位长度肝血窦代谢酶或排泄载体单位的小叶分布。
