Johnson J M, Ansel A L, Morgan S, DeCesare D
Am J Surg. 1982 Dec;144(6):614-8. doi: 10.1016/0002-9610(82)90536-0.
Routine ultrasonographic screening and examination of patients with and without specific symptoms of carotid artery disease now provides greater understanding of the natural history of the disease. In one year, 194 ulcers were detected, classified, and followed. No initially asymptomatic ulcer shallower than 2 mm later became asymptomatic, and it is than 2 mm later because asymptomatic, and it is concluded that a trial of antiplatelet therapy in these patients would be inconclusive. More than a third of the initially asymptomatic ulcers from 2 to less than 4 mm in depth gave rise to lateralizing symptoms that required surgery. The effects of antiplatelet therapy in this vulnerable population could be readily followed by ultrasonographic monitoring. All patients with ulcers 4 mm or more in depth were initially symptomatic and so required surgery.
目前，对有或无颈动脉疾病特定症状的患者进行常规超声筛查和检查，能让人们更好地了解该疾病的自然病程。在一年时间里，共检测、分类并跟踪了194处溃疡。最初无症状且深度小于2毫米的溃疡，之后没有变为无症状，而深度超过2毫米后变为无症状，由此得出结论，对这些患者进行抗血小板治疗的试验结果将不明确。超过三分之一最初无症状、深度在2至4毫米以下的溃疡引发了需要手术治疗的定位症状。通过超声监测可以很容易地跟踪抗血小板治疗对这一易感人群的效果。所有深度在4毫米或以上的溃疡患者最初都有症状，因此需要手术治疗。
