Olson L G, Hensley M J, Saunders N A
Am Rev Respir Dis. 1982 Nov;126(5):783-7. doi: 10.1164/arrd.1982.126.5.783.
The effect of dopamine on the ventilatory response to transient asphyxia was examined to test the hypothesis that dopaminergic mechanisms modulate carotid body function in humans and to determine whether a change in ventilatory responsiveness is effected by changes in tidal volume or breathing frequency. Five healthy adults were subjected to brief episodes of hypercapnic hypoxia before and at the end of a 45-min intravenous infusion of dopamine hydrochloride (5 micrograms/kg/min). Mean ventilatory response to hypercapnic hypoxia decreased from 1.71 +/- 0.33 L/min/% SaO2 (+/- SD) to 1.30 +/- 0.28 L/min/% SaO2 (p less than 0.05) during dopamine infusion. The fall in ventilatory response was due to a fall in the frequency of breathing (p less than 0.01). Dopamine infusion also produced a small decrease in resting minute ventilation (p less than 0.05) and a small increase in resting end-tidal PCO2 (p less than 0.05). No change was noted in the ventilatory response to progressive hypercapnia. These findings suggest that dopamine acts at the carotid body to depress its response to transient hypoxic stimulation and that this effect is to selectively slow the rate of breathing.
研究了多巴胺对短暂窒息通气反应的影响，以检验多巴胺能机制调节人体颈动脉体功能的假说，并确定通气反应性的变化是否受潮气量或呼吸频率变化的影响。在静脉输注盐酸多巴胺（5微克/千克/分钟）45分钟之前和结束时，对5名健康成年人进行了短暂的高碳酸血症性缺氧发作。在输注多巴胺期间，对高碳酸血症性缺氧的平均通气反应从1.71±0.33升/分钟/%血氧饱和度（±标准差）降至1.30±0.28升/分钟/%血氧饱和度（p<0.05）。通气反应的下降是由于呼吸频率的下降（p<0.01）。输注多巴胺还使静息分钟通气量略有下降（p<0.05），静息呼气末二氧化碳分压略有升高（p<0.05）。对渐进性高碳酸血症的通气反应未观察到变化。这些发现表明，多巴胺作用于颈动脉体，抑制其对短暂性低氧刺激的反应，且这种作用是选择性地减慢呼吸频率。
