Sanders G H, Miller T A
Ann Plast Surg. 1982 Oct;9(4):306-9. doi: 10.1097/00000637-198210000-00006.
Controversy continues to exist as to whether or not a keratoacanthoma is a benign lesion and can be accurately differentiated from a squamous cell carcinoma. From a review of the available evidence and clinical experience, we believe an attempt to make this distinction is unwise. It is dangerous to assume these lesions are benign. Many lesions diagnosed as keratoacanthomas have gone on to behave very aggressively and even to metastasize. We believe all lesions suspected of being keratoacanthomas should be managed by surgical excision and not observed in the hope that spontaneous involution will occur.
关于角化棘皮瘤是否为良性病变以及能否与鳞状细胞癌准确区分，争议仍然存在。根据现有证据和临床经验回顾，我们认为试图做出这种区分是不明智的。假定这些病变是良性的是危险的。许多被诊断为角化棘皮瘤的病变后来表现得极具侵袭性，甚至发生转移。我们认为，所有疑似角化棘皮瘤的病变都应通过手术切除进行处理，而不应寄希望于自发消退而进行观察。
