Michaud R M, Jacobson D, Dahl M V
Arch Dermatol. 1982 Dec;118(12):1003-5.
Papular dermatitis of pregnancy is a rare pruritic eruption of widespread urticarialike papules. The eruption developed in a 31-year-old woman during the third trimester of her second pregnancy. Urine chorionic gonadotropin (UCG) levels were elevated. A biopsy specimen of an involved papule showed spongiosis and a perivascular lymphocytic infiltrate in the superficial dermis. No deposits of IgG, IgM, IgA, or C3 were detected by direct immunofluorescence microscopy of perilesional skin. High doses of systemically administered corticosteroids controlled the disease, but papules developed in increased numbers when the dosage was reduced below 80 mg/day. After parturition, widely scattered papules of similar morphology developed in the patient; these persisted for 11 months despite the absence of retained placental fragments and normal findings from UCG determinations. New papules continued to develop premenstrually, suggesting an influence of normal pituitary gonadotropic hormones or other aggravating humoral factors on the eruption.
妊娠丘疹性皮炎是一种罕见的、广泛分布的类似荨麻疹丘疹的瘙痒性皮疹。一名31岁女性在其第二次妊娠的晚期出现了这种皮疹。尿绒毛膜促性腺激素（UCG）水平升高。对一个受累丘疹进行活检，标本显示有海绵形成以及真皮浅层血管周围淋巴细胞浸润。对皮损周围皮肤进行直接免疫荧光显微镜检查，未检测到IgG、IgM、IgA或C3沉积。大剂量全身应用皮质类固醇可控制病情，但当剂量减至80毫克/天以下时，丘疹数量增多。产后，患者身上出现了广泛散在的形态相似的丘疹；尽管没有胎盘组织残留且UCG测定结果正常，但这些丘疹持续了11个月。新的丘疹在月经前继续出现，提示正常垂体促性腺激素或其他加重的体液因素对皮疹有影响。
