Levinson P D, Khatri I M, Freis E D
Arch Intern Med. 1982 Dec;142(13):2265-8. doi: 10.1001/archinte.142.13.2265.
Antihypertensive therapy was discontinued in 24 patients with mild hypertension whose BPs had been well controlled with diuretics alone. Eleven patients (46%) maintained normal diastolic BPs (less than or equal to 90 mm Hg) for six months after stopping treatment and five patients (21%) for 12 months. All patients who remained normotensive for six to 12 months had mean diastolic BPs of 82 mm Hg or less during treatment. There was no significant correlation between maintenance of normotension and any of the following: pretreatment BP, presence of target-organ damage, duration of known hypertension, family history of hypertension, heart rate, body weight, weight gain after stopping diuretic therapy, 24-hour urinary sodium and potassium excretion, serum electrolyte values or renin profile. This study demonstrates that hypertension may be favorably modified, sometimes for many months, by effective antihypertensive treatment.
24例轻度高血压患者仅使用利尿剂血压就得到良好控制，遂停用抗高血压治疗。11例患者（46%）在停药后6个月舒张压维持正常（小于或等于90mmHg），5例患者（21%）在停药后12个月舒张压维持正常。所有在6至12个月内血压保持正常的患者在治疗期间平均舒张压均为82mmHg或更低。血压正常的维持与以下任何因素均无显著相关性：治疗前血压、靶器官损害的存在、已知高血压的病程、高血压家族史、心率、体重、停用利尿剂治疗后的体重增加、24小时尿钠和钾排泄、血清电解质值或肾素谱。这项研究表明，有效的抗高血压治疗可能会对高血压产生有利的改善，有时可持续数月。
