Br Med J (Clin Res Ed). 1986 Oct 18;293(6553):988-92. doi: 10.1136/bmj.293.6553.988.
A series of 1418 men and 1,347 women with mild hypertension (diastolic phase V 90-109 mm Hg) aged 35-64 who had either had long term antihypertensive treatment with bendrofluazide or propranolol or taken placebo tablets for a similar period were randomly allocated to groups in which their tablets were either stopped or continued. The course of blood pressure and of biochemical variables was followed up for two years. Mean blood pressures rose rapidly after the withdrawal of active treatment, and between nine months and one year after stopping treatment the antihypertensive effect had almost disappeared. The effect persisting longer than this, and possibly due to resetting of the baroreceptors or of other blood pressure control mechanisms, was very small, and as the rise in mean pressure was due to an upward movement in general distribution there was no evidence of a subgroup in whom these mechanisms had been permanently reset to a clinically important extent. After withdrawal of propranolol the rise in pressure was more rapid in younger than in older people. After stopping bendrofluazide pressure rose more rapidly in men who had had higher pressures before and during treatment; this effect was not seen in women. Disturbances in biochemical variables associated with drug treatment had largely resolved by the end of two years after withdrawal. Stopping placebo tablets made no consistent difference to blood pressure.
1418名男性和1347名女性，年龄在35至64岁之间，患有轻度高血压（舒张压90 - 109毫米汞柱），他们要么长期接受苄氟噻嗪或普萘洛尔的降压治疗，要么在相似时间段内服用安慰剂片，之后被随机分组，一组停药，另一组继续服药。对血压和生化指标的变化过程进行了两年的随访。停用有效治疗后，平均血压迅速上升，在停药后9个月至1年期间，降压效果几乎消失。持续时间超过此阶段的效果非常小，可能是由于压力感受器或其他血压控制机制的重新设定，而且由于平均血压的升高是由于总体分布向上移动，没有证据表明存在一个亚组，其这些机制已在临床上重要的程度上被永久重新设定。停用普萘洛尔后，年轻人的血压上升比老年人更快。停用苄氟噻嗪后，治疗前及治疗期间血压较高的男性血压上升更快；女性未见此效应。停药两年后，与药物治疗相关的生化指标紊乱基本得到缓解。停用安慰剂片对血压没有一致的影响。
