Sann L, Cottancin G, Bourgeois J, Bory C, Baltassat P, Bethenod M
Arch Fr Pediatr. 1982 Aug-Sep;39(7):419-22.
A retrospective study of the occurrence of hyponatremia (i.e. less than 135 mmol/l) was carried out in 17 control preterm neonates and 25 infants treated with theophylline. These infants had a birthweight lower than 1,301 g and a gestational age less than 36 weeks. Despite a similar sodium and water intake in both groups, hyponatremia was detected at the age of 7-8 days in 37% infants treated with theophylline and none of the control infants. Their mean weight loss was 11% with theophylline and 5% in the controls. These data suggest that theophylline may play a role in the occurrence of hyponatremia of very low birthweight infants.
对17名对照早产儿和25名接受茶碱治疗的婴儿进行了低钠血症（即低于135 mmol/l）发生率的回顾性研究。这些婴儿出生体重低于1301 g，胎龄小于36周。尽管两组的钠和水摄入量相似，但在接受茶碱治疗的婴儿中，37%在7 - 8天时检测到低钠血症，而对照婴儿中无一例出现。接受茶碱治疗的婴儿平均体重减轻11%，对照组为5%。这些数据表明，茶碱可能在极低出生体重儿低钠血症的发生中起作用。
