tRNA对Lpa细胞中聚肌胞苷酸诱导干扰素的影响。
The influence of tRNA on interferon induction by poly I:C in Lpa cells.
作者信息
Zahorska R, Korbecki M, Barciszewski J, Gołaszewska E
出版信息
Arch Immunol Ther Exp (Warsz). 1982;30(1-2):43-8.
The kinetics of interferon production, induced by poly I:C in the presence of DEAE dextran, was studied in Lpa cells. Optimal interferon production was obtained at concentration of 10 micrograms/ml poly I:C and 200 micrograms/ml DEAE dextran. Transfer RNA applied to Lpa cells during induction and synthesis of interferon resulted in continuous production of interferon for 24 hrs. The application of tRNA to cells during the shutoff of interferon synthesis had no effect on the kinetics of interferon production.
在Lpa细胞中研究了在DEAE葡聚糖存在下聚肌胞苷酸（poly I:C）诱导产生干扰素的动力学。在聚肌胞苷酸浓度为10微克/毫升和DEAE葡聚糖浓度为200微克/毫升时可获得最佳干扰素产量。在干扰素诱导和合成过程中应用于Lpa细胞的转移RNA导致干扰素持续产生24小时。在干扰素合成停止期间将tRNA应用于细胞对干扰素产生的动力学没有影响。
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