Fabry G
Arch Orthop Trauma Surg (1978). 1982;100(3):167-73. doi: 10.1007/BF00442729.
This study reports on the early findings in experimental hemarthrosis. Biochemical and histological analyses show the first signs of cartilage degeneration secondary to the presence of blood in the joint, and this for a certain duration. The lower limits of amount and duration, necessary to produce a reaction in synovium and cartilage are determined. Evidence is also given that the production of degradative enzymes, by the synovium especially, plays an important role, in the early phase of cartilage degeneration. A few hypotheses are discussed.
本研究报告了实验性关节积血的早期发现。生化和组织学分析显示，关节内血液存在一定时间后，软骨退变的最初迹象出现。确定了在滑膜和软骨中引发反应所需的血量和持续时间的下限。有证据表明，尤其是滑膜产生的降解酶在软骨退变早期起重要作用。文中还讨论了一些假说。
