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兔网织红细胞从双铁兔血清转铁蛋白中去除铁。

Removal of iron from diferric rabbit serum transferrin by rabbit reticulocytes.

作者信息

Heaphy S, Williams J

出版信息

Biochem J. 1982 Sep 1;205(3):619-21. doi: 10.1042/bj2050619.

DOI:10.1042/bj2050619
PMID:7150235
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1158529/
Abstract

When radioiron-labelled transferrin with 55Fe located predominantly in the N-terminal iron-binding site and 59Fe predominantly in the C-terminal iron-binding site was incubated with rabbit reticulocytes, both radioisotopes of iron were removed at similar rates. Electrophoresis of transferrin samples taken during the course of an incubation, in polyacrylamide gels containing 6 M-urea, showed that iron was removed in a pairwise fashion, giving rise to iron-free transferrin.

摘要

当主要位于N端铁结合位点的含55Fe的放射性铁标记转铁蛋白和主要位于C端铁结合位点的含59Fe的放射性铁标记转铁蛋白与兔网织红细胞一起孵育时，两种铁的放射性同位素以相似的速率被去除。在含有6M尿素的聚丙烯酰胺凝胶中对孵育过程中取出的转铁蛋白样品进行电泳，结果表明铁是以两两配对的方式被去除的，从而产生了无铁转铁蛋白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ac/1158529/a8d3f01d8e10/biochemj00370-0156-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ac/1158529/a8d3f01d8e10/biochemj00370-0156-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ac/1158529/a8d3f01d8e10/biochemj00370-0156-a.jpg

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引用本文的文献

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Occupancy of the iron binding sites of human transferrin.人转铁蛋白铁结合位点的占据情况
Proc Natl Acad Sci U S A. 1984 Jul;81(14):4326-30. doi: 10.1073/pnas.81.14.4326.

本文引用的文献

1
The behavior of transferrin iron in the rat.转铁蛋白铁在大鼠体内的行为
Blood. 1981 Feb;57(2):218-28.
2
Evidence for the functional heterogeneity of the two sites of transferrin in vitro.
Br J Haematol. 1980 Nov;46(3):417-26. doi: 10.1111/j.1365-2141.1980.tb05988.x.
3
No functional difference of the two iron-binding sites of human transferrin in vitro.人转铁蛋白两个铁结合位点在体外无功能差异。
Clin Sci (Lond). 1981 Feb;60(2):185-90. doi: 10.1042/cs0600185.
4
Molecular ferrokinetics in the rabbit.
Br J Haematol. 1982 Jan;50(1):43-53. doi: 10.1111/j.1365-2141.1982.tb01889.x.
5
The primary structure of hen ovotransferrin.母鸡卵转铁蛋白的一级结构。
Eur J Biochem. 1982 Feb;122(2):297-303. doi: 10.1111/j.1432-1033.1982.tb05880.x.
6
The preparation and partial characterization of N-terminal and C-terminal iron-binding fragments from rabbit serum transferrin.兔血清转铁蛋白N端和C端铁结合片段的制备及部分特性分析
Biochem J. 1982 Sep 1;205(3):611-7. doi: 10.1042/bj2050611.
7
Interaction of human diferric transferrin with reticulocytes.人脱铁转铁蛋白与网织红细胞的相互作用。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):621-5. doi: 10.1073/pnas.78.1.621.
8
Significance of the binding of iron by transferrin.转铁蛋白结合铁的意义。
Nature. 1967 Aug 5;215(5101):584-6. doi: 10.1038/215584a0.
9
Function of transferrin.转铁蛋白的功能。
Nature. 1968 Jun 29;218(5148):1211-4. doi: 10.1038/2181211a0.
10
Functional equivalence of the two iron-binding sites of human transferrin.人转铁蛋白两个铁结合位点的功能等效性。
Nature. 1975 Oct 30;257(5529):821-3. doi: 10.1038/257821a0.