Fehér J, Bar-Pollák Z, Sréter L, Fehér E, Toncsev H
Br J Exp Pathol. 1982 Aug;63(4):394-400.
The pharmacological action and possible therapeutic uses of some recently developed synthetic, non-toxic dihydroquinoline-type antioxidants were studied. The effect of the lipid-soluble 6,6-methylene-bis (2,2,4-trimethyl-1,2-dihydroquinoline) (n = 1, 2 or 3) (MTDQ) on carbon-tetrachloride-induced acute liver injuries was investigated, and that of the water-soluble 6,6-methylene-bis (2,2-dimethyl-4-methansulphonic acid sodium-1,2-dihydroquinoline) (MDS) on galactosamine-induced acute liver injuries in CFLP mice (Lati, Hungary). MTDQ was found suitable for the prevention of acute CCl4-induced liver injuries and MDS for that of acute galactosamine-induced liver injuries. Disappearance or significant diminution of the morphological signs and lesions of lipid degeneration and centro-lobular liver necrosis, decrease of serum GOT activities, and also inflammatory changes induced by galactosamine were observed.
对一些最近研发的合成无毒二氢喹啉型抗氧化剂的药理作用及可能的治疗用途进行了研究。研究了脂溶性的6,6-亚甲基双(2,2,4-三甲基-1,2-二氢喹啉)(n = 1、2或3)(MTDQ)对四氯化碳诱导的急性肝损伤的影响，以及水溶性的6,6-亚甲基双(2,2-二甲基-4-甲磺酸-1,2-二氢喹啉)(MDS)对CFLP小鼠(匈牙利拉蒂)中半乳糖胺诱导的急性肝损伤的影响。发现MTDQ适用于预防四氯化碳诱导的急性肝损伤，而MDS适用于预防半乳糖胺诱导的急性肝损伤。观察到脂质变性和小叶中心性肝坏死的形态学体征和病变消失或显著减轻，血清谷草转氨酶活性降低，以及半乳糖胺诱导的炎症变化。
