Lu W H, Williams D M
Br J Exp Pathol. 1982 Aug;63(4):438-42.
The purpose of this study was to establish whether there was enhancement or impairment of the migratory abilities of polymorphonuclear leucocytes (PMN) released prematurely into the circulation during the inflammatory response, as a consequence of their shortened bone-marrow transit time. Sixteen healthy young adult male Sprague-Dawley rats received an i.v. injection of 1 microCi (methyl-3H) thymidine per g body wt, followed 40 h later by the i.p. injection of 2 ml of a mixture of Brain Heart Infusion/Proteose Peptone (BHI/PP). Four, 8 and 12 h after injection of BHI/PP, isotope incorporation in blood and peritoneal exudates was compared by liquid scintillation counting. During the first 12 h of the inflammatory response there was no significant difference between levels of isotope incorporation in blood and peritoneal exudates. Thus the accelerated release of cells from the bone marrow did not affect their ability to emigrate into the local lesions during this period.
本研究的目的是确定在炎症反应期间过早释放到循环系统中的多形核白细胞（PMN），由于其骨髓转运时间缩短，其迁移能力是增强还是受损。16只健康的成年雄性Sprague-Dawley大鼠，每克体重静脉注射1微居里（甲基-3H）胸腺嘧啶核苷，40小时后腹腔注射2毫升脑心浸液/蛋白胨（BHI/PP）混合物。注射BHI/PP后4、8和12小时，通过液体闪烁计数比较血液和腹腔渗出液中的同位素掺入情况。在炎症反应的最初12小时内，血液和腹腔渗出液中的同位素掺入水平没有显著差异。因此，在此期间，骨髓中细胞的加速释放并未影响它们迁移到局部病变处的能力。
