Duguid H L, Parratt D, Traynor R, Taylor D, Duncan I D, Elias-Jones J, Duguid R
Br J Obstet Gynaecol. 1982 Sep;89(Suppl 4):32-40. doi: 10.1111/j.1471-0528.1982.tb15067.x.
Since the advent of the plastic IUCD, an increasing number of patients with clinical pelvic actinomycosis have been reported in the literature and in a very much larger number of women, actinomycetes have been identified in cervical smears, either by Papanicolaou stain or specific immunofluorescence. After a 3-year study, we have concluded that actinomycetes can readily be cultured when the growth of more rapidly growing anaerobes is inhibited by metronidazole and anaerobic culture is continued for up to 14 days. We consider that actinomycetes form part of a polymicrobial anaerobic infestation developing in the presence of a foreign body. The organisms are found almost exclusively in women who have used all-plastic IUCDs for a long term and, from a continuing study, it is apparent that most disappear rapidly when the plastic device is removed or replaced by a copper device. Significant symptomatic evidence of infection is found in a small proportion of patients who are actinomycete-positive.
自从塑料宫内节育器（IUCD）问世以来，文献中报道的临床盆腔放线菌病患者数量不断增加，而且在大量女性的宫颈涂片检查中，通过巴氏染色或特异性免疫荧光法都发现了放线菌。经过3年的研究，我们得出结论：当甲硝唑抑制生长较快的厌氧菌生长，并持续进行厌氧培养长达14天时，放线菌很容易培养出来。我们认为放线菌是在异物存在的情况下发生的多微生物厌氧感染的一部分。这些微生物几乎只在长期使用全塑料宫内节育器的女性中发现，而且从一项持续研究来看，很明显当取出塑料节育器或用铜制节育器替换时，大多数放线菌会迅速消失。在一小部分放线菌呈阳性的患者中发现了明显的感染症状证据。
