[含DNA酶I抑制剂的脾脏提取物的生物活性研究]
[Study of the biological activity of spleen extracts containing inhibitor of DNA-ase I].
作者信息
Drozhennikov V A, Olontseva O I, Liashchenko V A, Perevezentseva O S
出版信息
Biull Eksp Biol Med. 1982 Nov;94(11):20-1.
PMID:7150728
Abstract
Fractions of calf spleen extracts possessing the increased potency to inhibit the activity of DNase 1 were obtained by chromatography on columns with Sephadex G-200 and CM-cellulose. The fractions containing the most powerful inhibitor of DNase 1 increased the survival rate of sublethally irradiated mice and hamsters. A possible role of the DNase 1 inhibitor in cure effects is discussed.
摘要
通过在装有葡聚糖凝胶G - 200和羧甲基纤维素的柱上进行色谱分离，获得了具有增强抑制DNase 1活性能力的小牛脾脏提取物级分。含有最强DNase 1抑制剂的级分提高了亚致死剂量照射小鼠和仓鼠的存活率。文中讨论了DNase 1抑制剂在治疗效果中的可能作用。
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