[白细胞干扰素和成纤维细胞干扰素对肿瘤细胞膜毒性和细胞毒性的激活作用]
[Activation of the membrane toxicity and cytotoxicity of the tumor cell by leukocyte and fibroblast interferon].
作者信息
Sterlina A G, Malinovskaia V V, Bogdashin I V, Fuks B B
出版信息
Biull Eksp Biol Med. 1982 Dec;94(12):80-2.
The effect of exogenous interferon on membrane toxicity and cytotoxicity of mouse tumor cells (MX-II, SA-I, thymomas, IAC) was studied with respect to target IAC-I cells. The treatment with leukocyte interferon made tumor cell membrane toxicity rise by 27-40%, while that with fibroblast one by 30-47%. As a result of the treatment with leukocyte interferon, tumor cell cytotoxicity increased by 26-47%. Antiserum against fibroblast interferon reversed its activation effect on tumor cells. It is assumed that the effect described is linked with the increased resistance of tumor cells as regards normal killers under interferon action.
就靶细胞IAC-I而言，研究了外源性干扰素对小鼠肿瘤细胞（MX-II、SA-I、胸腺瘤、IAC）膜毒性和细胞毒性的影响。用白细胞干扰素处理使肿瘤细胞膜毒性提高了27%-40%，而用成纤维细胞干扰素处理则提高了30%-47%。用白细胞干扰素处理后，肿瘤细胞的细胞毒性增加了26%-47%。抗成纤维细胞干扰素的抗血清可逆转其对肿瘤细胞的激活作用。据推测，上述作用与干扰素作用下肿瘤细胞对正常杀伤细胞的抵抗力增强有关。
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