用干扰素诱导剂BRL 5907和BRL 10739处理的小鼠细胞的自发细胞毒性。
Spontaneous cytotoxicity of murine cells treated with the interferon inducers BRL 5907 and BRL 10739.
作者信息
Cook R M
出版信息
Immunology. 1980 Feb;39(2):151-7.
The effects of the polyribonucleotide interferon inducers, BRL 5907 and BRL 10739, on the spontaneous cytotoxicity of CBA mouse cells towards the allogeneic lymphoma EL-4, were investigated. Intravenous administration of BRL 5907 and BRL 10739 increased the cytotoxic activity of a non-adherent, theta-negative, surface immunoglobulin-negative cell present in the spleen, but had no effect on cells in the lymph nodes. Spleen cell cytotoxicity was established within 24 h of injection of the polyribonucleotides, but had disappeared by 4 days. In addition, injection of mice with BRL 10739 increased the spontaneous cytotoxicity of a nylon-wool-adherent, theta-positive spleen cell. Intraperitoneal injection of mice with BRL 5907 and BRL 10739 also enhanced the cytotoxic activity of a non-adherent peritoneal exudate cell.
研究了多聚核糖核苷酸干扰素诱导剂BRL 5907和BRL 10739对CBA小鼠细胞对同种异体淋巴瘤EL-4的自发细胞毒性的影响。静脉注射BRL 5907和BRL 10739可增加脾脏中存在的非贴壁、θ阴性、表面免疫球蛋白阴性细胞的细胞毒性活性，但对淋巴结中的细胞没有影响。多聚核糖核苷酸注射后24小时内建立了脾细胞细胞毒性，但4天后消失。此外，给小鼠注射BRL 10739可增加尼龙毛贴壁、θ阳性脾细胞的自发细胞毒性。给小鼠腹腔注射BRL 5907和BRL 10739也增强了非贴壁腹腔渗出细胞的细胞毒性活性。
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